Title : Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

Pub. Date : 2001 Jan 10

PMID : 11179691






1 Functional Relationships(s)
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1 Therefore, rats and mice have the unusual capacity to convert cholesterol to bile acids by LXRalpha-mediated stimulation of CYP7A1 transcription, whereas other species do not respond to cholesterol and develop hypercholesterolemia on a diet high in cholesterol. Cholesterol nuclear receptor subfamily 1, group H, member 3 Mus musculus