Title : Prolactin and Leydig cells: biphasic effects of prolactin on LH-, T3- and GH-induced testosterone/oestradiol secretion by Leydig cells in pubertal rats.

Pub. Date : 2001 Feb

PMID : 11168650






3 Functional Relationships(s)
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1 The effect of rat prolactin (rPRL) on basal and LH-, GH- and T3-mediated testosterone and oestradiol secretion was studied in pubertal rat Leydig cells. Luteinizing Hormone prolactin Rattus norvegicus
2 While a maximum effective dose of rPRL (200 ng) did not alter LH (25 ng)-induced testosterone and oestradiol secretion, it inhibited testosterone secretion induced by 100 ng LH and increased oestradiol secretion. Luteinizing Hormone prolactin Rattus norvegicus
3 The present in vitro study indicates that rPRL stimulates both testosterone and oestradiol secretion by Leydig cells and that this effect can be modulated by LH, GH and T3. Luteinizing Hormone prolactin Rattus norvegicus