Pub. Date : 2001 Feb
PMID : 11159731
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Intracellular accumulation of calcein, an anionic dye substrate for MRP1, was strongly increased by glibenclamide in a dose-dependent manner in MRP1-overexpressing lung tumour GLC4/Sb30 cells through inhibition of MRP1-related calcein efflux. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Intracellular accumulation of calcein, an anionic dye substrate for MRP1, was strongly increased by glibenclamide in a dose-dependent manner in MRP1-overexpressing lung tumour GLC4/Sb30 cells through inhibition of MRP1-related calcein efflux. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Intracellular accumulation of calcein, an anionic dye substrate for MRP1, was strongly increased by glibenclamide in a dose-dependent manner in MRP1-overexpressing lung tumour GLC4/Sb30 cells through inhibition of MRP1-related calcein efflux. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Glibenclamide used at 12.5 microM was, moreover, found to strongly enhance the sensitivity of GLC4/Sb30 cells towards vincristine, an anticancer drug handled by MRP1. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In summary, glibenclamide reversed MRP1-mediated drug resistance likely through inhibiting MRP1 activity and blocked organic anion efflux from MRP2-expressing hepatocytes. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | In summary, glibenclamide reversed MRP1-mediated drug resistance likely through inhibiting MRP1 activity and blocked organic anion efflux from MRP2-expressing hepatocytes. | Glyburide | ATP binding cassette subfamily B member 1 | Homo sapiens |