Title : Induction of anergy in Th1 cells associated with increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1.

Pub. Date : 2001 Jan 15

PMID : 11145672






2 Functional Relationships(s)
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1 Subsequent experiments to delineate the nature of the protein apparently required for n-butyrate-induced Th1 cell anergy focused on the role of cyclin-dependent kinase (cdk) inhibitors p21(Cip1) and p27(Kip1). Butyrates cyclin dependent kinase inhibitor 1B Homo sapiens
2 Consequently, it appears that n-butyrate-induced anergy in Th1 cells correlated with the up-regulation of p21(Cip1) and perhaps the downstream failure to maintain low levels of p27(Kip1). Butyrates cyclin dependent kinase inhibitor 1B Homo sapiens