Pub. Date : 2001 Jan 1
PMID : 11141357
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 2 | To understand whether BghiP enhances BaP-induced CYP1A1 gene expression through the aryl hydrocarbon receptor (AhR) signaling pathway, a gel retardation assay was performed to elucidate the synergistic mechanism of BghiP in BaP-induced CYP1A1 gene expression. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 3 | Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 4 | Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |