Title : Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages.

Pub. Date : 2000 Dec

PMID : 11131166






1 Functional Relationships(s)
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1 Interestingly, compounds almost equally effective in inhibiting nitrite accumulation did not show the same cytotoxic potential, and most sesquiterpene lactones inhibited nitrite accumulation at concentrations where inhibition of NF-kappaB activation was not significant. Nitrites nuclear factor kappa B subunit 1 Homo sapiens