Pub. Date : 2001 Apr 13
PMID : 11124258
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proper folding and endoplasmic reticulum to golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine. | Dihydroxyphenylalanine | tyrosinase | Homo sapiens |
| 2 | Here, we demonstrate that the substrates DOPA and tyrosine induced in melanoma cells a transition of misfolded wild type tyrosinase to the native form that is resistant to proteolysis, competent to exit the endoplasmic reticulum, and able to produce melanin. | Dihydroxyphenylalanine | tyrosinase | Homo sapiens |
| 3 | Because the enzymatic activity of tyrosinase is induced by DOPA, we propose that proper folding of the wild type protein, just like mutant forms, is tightly linked to its catalytic state. | Dihydroxyphenylalanine | tyrosinase | Homo sapiens |
| 4 | Loss of pigmentation, therefore, in tyrosinase-positive melanoma cells is a consequence of tumor-induced metabolic changes that suppress tyrosinase activity and DOPA production within these cells. | Dihydroxyphenylalanine | tyrosinase | Homo sapiens |