Pub. Date : 2001 Jan
PMID : 11123357
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adrenal tyrosine hydroxylase activity and gene expression are increased by intraventricular administration of nicotine. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 2 | When nicotine is administered s.c. to rats, tyrosine hydroxylase (TH) enzyme activity and TH gene transcription rate are activated, and TH mRNA and TH protein are induced in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 3 | When nicotine is administered s.c. to rats, tyrosine hydroxylase (TH) enzyme activity and TH gene transcription rate are activated, and TH mRNA and TH protein are induced in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 4 | When nicotine is administered s.c. to rats, tyrosine hydroxylase (TH) enzyme activity and TH gene transcription rate are activated, and TH mRNA and TH protein are induced in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 5 | When nicotine is administered s.c. to rats, tyrosine hydroxylase (TH) enzyme activity and TH gene transcription rate are activated, and TH mRNA and TH protein are induced in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 6 | When nicotine is administered s.c. to rats, tyrosine hydroxylase (TH) enzyme activity and TH gene transcription rate are activated, and TH mRNA and TH protein are induced in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 7 | administration of nicotine produces a dose-dependent activation of adrenal TH, which is blocked by i.v.t. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 8 | We also show that surgical transection of the splanchnic nerve blocks the activation of adrenal TH by i.v.t.-administered nicotine. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 9 | administration of nicotine over a 3-h period (injections spaced 30 min apart) leads to a sustained activation of adrenal TH, suggesting that this central response to nicotine does not readily desensitize. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 10 | administration of nicotine over a 3-h period (injections spaced 30 min apart) leads to a sustained activation of adrenal TH, suggesting that this central response to nicotine does not readily desensitize. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 11 | Intraventricular administration of nicotine also stimulates the TH gene transcription rate in rat adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 12 | or s.c. over 3 h, nicotine induces adrenal TH mRNA. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 13 | This induction is dependent on innervation of the adrenal medulla, even when the drug is injected s.c. Our results demonstrate that the central effects of nicotine are sufficient to activate TH and induce TH gene expression in rat adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 14 | This induction is dependent on innervation of the adrenal medulla, even when the drug is injected s.c. Our results demonstrate that the central effects of nicotine are sufficient to activate TH and induce TH gene expression in rat adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 15 | Furthermore, our results suggest that this centrally mediated response to nicotine is essential for the induction of adrenal TH mRNA. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |