Title : The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.

Pub. Date : 2001 Apr 6

PMID : 11118434






1 Functional Relationships(s)
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1 We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this switch in MUC1 glycosylation that results in the expression of the cancer-associated SM3 epitope. N-Acetylneuraminic Acid ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Homo sapiens