Title : Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

Pub. Date : 2000 Dec 20

PMID : 11118286






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GCLC owns the catalytic activity, whereas GCLM enhances the enzyme activity by lowering the K(m) for glutamate and increasing the K(i) to GSH inhibition. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus