Pub. Date : 2000 Nov
PMID : 11108662
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of GSTP1-1 was associated with a fourfold to tenfold protection from 4NQO-induced cytotoxicity. | 4-Nitroquinoline-1-oxide | glutathione S-transferase pi 1 | Homo sapiens |
| 2 | Moreover, MRP2 efflux activity also augmented GSTP1-1-mediated protection from 4NQO-induced nucleic-acid adduct formation. | 4-Nitroquinoline-1-oxide | glutathione S-transferase pi 1 | Homo sapiens |
| 3 | We conclude that MRP2-mediated efflux of the glutathione conjugate of 4NQO and/or another toxic derivative of 4NQO is required to support GSTP1-1-associated protection from 4NQO toxicities in HepG2 cells. | 4-Nitroquinoline-1-oxide | glutathione S-transferase pi 1 | Homo sapiens |
| 4 | We conclude that MRP2-mediated efflux of the glutathione conjugate of 4NQO and/or another toxic derivative of 4NQO is required to support GSTP1-1-associated protection from 4NQO toxicities in HepG2 cells. | 4-Nitroquinoline-1-oxide | glutathione S-transferase pi 1 | Homo sapiens |