Pub. Date : 2000 Dec 6
PMID : 11106684
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, AP-1-dependent transcription (P=.04) and phosphorylated c-Jun and JNK levels (P<.001) were statistically significantly increased in the tamoxifen-resistant tumors. | Tamoxifen | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | CONCLUSION: Our results suggest that the conversion of breast tumors to a tamoxifen-resistant phenotype is associated with oxidative stress and the subsequent antioxidant response and with increased phosphorylated JNK and c-Jun levels and AP-1 activity, which together could contribute to tumor growth. | Tamoxifen | mitogen-activated protein kinase 8 | Homo sapiens |