Pub. Date : 2001 Mar 16
PMID : 11104774
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 2 | ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 3 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |