Title : Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion.

Pub. Date : 2000 Nov 1

PMID : 11063913






1 Functional Relationships(s)
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1 Both nonselective (N(G)-monomethyl-L-arginine) and specific (N-Iminoethyl-L-lysine) inhibitors of iNOS significantly increased leukocyte binding by normal HIMEC activated with cytokines and lipopolysaccharide (LPS), but had no effect on leukocyte adhesion by similarly activated IBD HIMEC. omega-N-Methylarginine nitric oxide synthase 2 Homo sapiens