Pub. Date : 2001 Feb 9
PMID : 11056157
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. | Adenosine Triphosphate | interleukin 18 | Homo sapiens |
| 2 | Despite its constitutive cytosolic presence, IL-18 required lipopolysaccharide priming for the ATP-induced release. | Adenosine Triphosphate | interleukin 18 | Homo sapiens |
| 3 | In evaluating the signaling components involved in the ATP effect, we identified that the protein-tyrosine kinase inhibitor, AG126, produced a profound inhibition of both ICE activation as well as release of IL-1beta/IL-18. | Adenosine Triphosphate | interleukin 18 | Homo sapiens |
| 4 | Taken together, these results suggest that, although synthesis of IL-1beta and IL-18 differ, ATP-mediated release of both cytokines requires a priming step but not proteolytically functional caspase-1. | Adenosine Triphosphate | interleukin 18 | Homo sapiens |