Pub. Date : 2000 Nov
PMID : 11038165
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the presence of liver cytosol, 3",4"-diHPPH formation activity from 100 microM 4"-HPPH was correlated with testosterone 6beta-hydroxylation activity and CYP3A4 content. | hydroxyphenytoin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Of 10 cDNA-expressed human P450 enzymes examined, CYP2C19, CYP2C9, and CYP3A4 catalyzed 3",4"-diHPPH formation from the primary hydroxylated metabolites (3"-hydroxy-DPH and 4"-HPPH). | hydroxyphenytoin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Fluvoxamine and anti-CYP2C antibody inhibited 3",4"-diHPPH formation from 10 microM 4"-HPPH in a human liver sample that contained relatively high levels of CYP2C, whereas ketoconazole and anti-CYP3A antibody showed inhibitory effects on the activities in liver microsomal samples in which CYP3A4 levels were relatively high. | hydroxyphenytoin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Fluvoxamine and anti-CYP2C antibody inhibited 3",4"-diHPPH formation from 10 microM 4"-HPPH in a human liver sample that contained relatively high levels of CYP2C, whereas ketoconazole and anti-CYP3A antibody showed inhibitory effects on the activities in liver microsomal samples in which CYP3A4 levels were relatively high. | hydroxyphenytoin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |