Pub. Date : 2000 Oct 18
PMID : 11036110
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BCRP can render tumor cells resistant to the anticancer drugs topotecan, mitoxantrone, doxorubicin, and daunorubicin. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | Bcrp1, the murine homologue of BCRP, was expressed in the polarized mammalian cell lines LLC-PK1 and MDCK-II, and the direction of Bcrp1-mediated transport of topotecan and mitoxantrone was determined. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | Bcrp1, the murine homologue of BCRP, was expressed in the polarized mammalian cell lines LLC-PK1 and MDCK-II, and the direction of Bcrp1-mediated transport of topotecan and mitoxantrone was determined. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | To avoid the confounding drug transport provided by P-glycoprotein (P-gp), the roles of Bcrp1 in the bioavailability of topotecan and the effect of GF120918 were studied in both wild-type and P-gp-deficient mice and their fetuses. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 5 | In pregnant GF120918-treated, P-gp-deficient mice, relative fetal penetration of topotecan was twofold higher than that in pregnant vehicle-treated mice, suggesting a function for BCRP in the maternal-fetal barrier of the placenta. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 6 | We propose that strategic application of BCRP inhibitors may thus lead to more effective oral chemotherapy with topotecan or other BCRP substrate drugs. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |