Pub. Date : 2000 Oct 1
PMID : 11032977
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently found with differential display polymerase chain reaction that valproate regulates the expression of the endoplasmic reticulum stress protein GRP78 in the rat cerebral cortex. | Valproic Acid | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 2 | METHODS: Immunohistochemistry was used to measure protein levels of GRP78, GRP94, and calreticulin after treatment with sodium valproate (300 mg/kg, intraperitoneal) in specific rat brain regions. | Valproic Acid | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 3 | CONCLUSIONS: Because GRP78, GRP94, and calreticulin possess molecular chaperone activity and bind Ca(2+) in the endoplasmic reticulum, the pharmacologic action of valproate may involve one or more of these processes. | Valproic Acid | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |