Pub. Date : 2000 Oct
PMID : 11011335
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Recent studies have shown that endothelin-1 (ET-1) antagonists increase sodium excretion and improve renal blood flow in experimental heart failure (HF). | Sodium | endothelin 1 | Homo sapiens |
| 2 | BACKGROUND: Recent studies have shown that endothelin-1 (ET-1) antagonists increase sodium excretion and improve renal blood flow in experimental heart failure (HF). | Sodium | endothelin 1 | Homo sapiens |
| 3 | Our aim was to investigate renal ET-1 formation and its relation to sodium excretion in patients with HF. | Sodium | endothelin 1 | Homo sapiens |
| 4 | In the 71 subjects who were not receiving diuretic treatment, urinary ET-1 was selected as the strongest predictor of sodium excretion by multivariate stepwise analysis. | Sodium | endothelin 1 | Homo sapiens |
| 5 | CONCLUSIONS: Urinary ET-1 excretion increases in an earlier phase of HF than plasma ET-1 and appears to be closely correlated with sodium excretion, indicating renal ET-1 is a target for ET-1 antagonists in patients with HF. | Sodium | endothelin 1 | Homo sapiens |