Title : Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice.

Pub. Date : 2000 Oct

PMID : 11009479






3 Functional Relationships(s)
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Protein Name
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1 Dilation to ACh was inhibited by N(G)-nitro-L-arginine, an inhibitor of NOS in control and eNOS -/- mice. Acetylcholine nitric oxide synthase 3, endothelial cell Mus musculus
2 In contrast, trifluoromethylphenylimidazole, an inhibitor of neuronal NOS (nNOS), decreased ACh-induced dilation in arteries from eNOS-deficient mice but had no effect on responses in wild-type mice. Acetylcholine nitric oxide synthase 3, endothelial cell Mus musculus
3 Indomethacin, an inhibitor of cyclooxygenase, decreased vasodilation to ACh in eNOS-deficient, but not wild-type, mice. Acetylcholine nitric oxide synthase 3, endothelial cell Mus musculus