Title : Bone morphogenetic protein inhibits ovarian androgen production.

Pub. Date : 2000 Sep

PMID : 10999829






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Forskolin treatment led to an increase in CYP17, CYP11A1, 3betaHSD, and StAR protein expression. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 BMP-4 markedly inhibited forskolin stimulation of CYP17 expression but had little effect on 3betaHSD, CYP11A1, or StAR protein levels. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens
3 In addition, BMP-4 inhibited basal and forskolin stimulation of CYP17 messenger RNA expression as determined by RNase protection assay. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens
4 Activin also inhibited forskolin induction of CYP17 protein expression as determined by Western analysis. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens