Title : IL-5-Induced JAB-JAK2 interaction.

Pub. Date : 2000 Sep

PMID : 10975987






2 Functional Relationships(s)
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Protein Name
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1 Since JAB has already been shown to bind JAK2 via a phosphorylated tyrosine, the current data suggest that JAB binds to phosphorylated JAK2, enhances JAK2 dephosphorylation and remains associated in a complex, with dephosphorylated JAK2, that may be a precursor leading to irreversible JAK2 degradation. Tyrosine suppressor of cytokine signaling 1 Homo sapiens
2 Since JAB has already been shown to bind JAK2 via a phosphorylated tyrosine, the current data suggest that JAB binds to phosphorylated JAK2, enhances JAK2 dephosphorylation and remains associated in a complex, with dephosphorylated JAK2, that may be a precursor leading to irreversible JAK2 degradation. Tyrosine suppressor of cytokine signaling 1 Homo sapiens