Title : Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution.

Pub. Date : 2000 Sep 4

PMID : 10974006






1 Functional Relationships(s)
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1 Here, we show by confocal laser microscopy, enzymatic assays, and immunoblotting that the synthetic glucocorticoid dexamethasone inhibited tumor necrosis factor alpha (TNF-alpha)-induced phosphorylation and activation of JNK in the cytoplasm and nucleus of intact HeLa cells. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens