Title : Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase.

Pub. Date : 2000 Sep 1

PMID : 10964950






2 Functional Relationships(s)
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1 Expression of dominant-interfering mutants of the JNK or p38 pathways inhibited apoptosis induced by arsenite, whereas expression of constitutive active mutants for either pathway induced apoptosis. arsenite mitogen-activated protein kinase 8 Homo sapiens
2 These data indicate that both JNK and p38 contribute to arsenite-induced apoptosis in primary CNS neurons, and this apoptosis requires the bcl-2-caspase pathway. arsenite mitogen-activated protein kinase 8 Homo sapiens