Title : Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas.

Pub. Date : 2000 Aug 24

PMID : 10962574






2 Functional Relationships(s)
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Protein Name
Organism
1 PD098059, a specific inhibitor of MEK, disminishes TGF-beta1-induced p21Cip1 levels in PDV but not in MCA3D cells, suggesting an involvement of Erk in up-regulation of p21Cip1 by TGF-beta1 in PDV cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Mus musculus
2 PD098059, a specific inhibitor of MEK, disminishes TGF-beta1-induced p21Cip1 levels in PDV but not in MCA3D cells, suggesting an involvement of Erk in up-regulation of p21Cip1 by TGF-beta1 in PDV cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Mus musculus