Title : Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.

Pub. Date : 2000 Sep

PMID : 10960365






1 Functional Relationships(s)
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1 After 14 days of treatment with the PARP inhibitor 3-aminobenzamide, IL-10 gene-deficient mice demonstrated normalized colonic permeability; reduced tumor necrosis factor-alpha and interferon-gamma secretion, inducible nitric oxide synthase expression, and nitrotyrosine levels; and significantly attenuated inflammation. 3-nitrotyrosine poly (ADP-ribose) polymerase family, member 1 Mus musculus