Pub. Date : 2000 Sep
PMID : 10960075
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. | SB 203580 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In fact, 5 and 10 microM SB203580 enhanced rather than inhibited NF-kappaB-mediated promoter activity by 2 fold, which was independent of phosphorylation of the p65 subunit. | SB 203580 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The SB203580-mediated increase in NF-kappaB transcriptional activity was associated with enhanced phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK), but not p38 kinase. | SB 203580 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Overexpression of kinase-deficient mutants belonging to the ERK1/2, JNK, and p38 pathways showed that only dominant-negative Raf-1 abrogated SB203580-enhanced NF-kappaB activity. | SB 203580 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | This would implicate the involvement of the ERK1/2 pathway in the enhancing effects of SB203580 on NF-kappaB-mediated gene transcription. | SB 203580 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-kappaB transcriptional activity. | SB 203580 | nuclear factor kappa B subunit 1 | Homo sapiens |