Title : Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats.

Pub. Date : 2000 Sep 15

PMID : 10956394






3 Functional Relationships(s)
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1 In this study, we demonstrate that systemic administration of low-dose TNF-alpha augments the antitumor activity of a liposomal formulation of doxorubicin (DOXIL(R)). liposomal doxorubicin tumor necrosis factor Rattus norvegicus
2 Addition of TNF-alpha to a DOXIL(R) regimen, which by itself induced some tumor growth delay, resulted in massive necrosis and regression of tumors. liposomal doxorubicin tumor necrosis factor Rattus norvegicus
3 Administration of TNF-alpha augmented DOXIL(R) accumulation only after repeated injections, whereas accumulation of free doxorubicin was not affected by TNF-alpha. liposomal doxorubicin tumor necrosis factor Rattus norvegicus