Pub. Date : 2000 Sep 15
PMID : 10956385
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Up-regulation of cdc2 protein during paclitaxel-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Microtubule damages induced by paclitaxel inhibit proteasome-dependent degradation of cyclin B, resulting in a sustained activation of cyclin B/cdc2 kinase and a cell cycle arrest in mitosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | We found here that paclitaxel increased cdc2 mRNA and protein levels and led to an accumulation of cdc2 in the active dephosphorylated form in NIH-OVCAR-3 cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | We found here that paclitaxel increased cdc2 mRNA and protein levels and led to an accumulation of cdc2 in the active dephosphorylated form in NIH-OVCAR-3 cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 5 | The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 6 | The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 7 | The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 8 | The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 9 | This increase in cdc2 synthesis is a consequence of paclitaxel-induced arrest in mitosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 10 | In addition, when paclitaxel-induced apoptosis was inhibited by Bcl-2 over-expression, cdc2 up-regulation did not occur, leading to a lower level of activation of the cyclin B/cdc2 complex. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 11 | In addition, when paclitaxel-induced apoptosis was inhibited by Bcl-2 over-expression, cdc2 up-regulation did not occur, leading to a lower level of activation of the cyclin B/cdc2 complex. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 12 | Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 13 | Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 14 | Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 15 | Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |