Pub. Date : 2000 Aug
PMID : 10954002
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation by sodium intake of type 1 angiotensin II receptor mRNAs in the kidney of Sabra rats. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 2 | OBJECTIVE: To study the relationship between the sensitivity to sodium content of the diet in terms of development of hypertension and the regulation of the expression of type 1 angiotensin II receptor subtypes by such a diet. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 3 | In the cortex (C) and inner stripe (IS), the high sodium diet decreased AT1A and AT1B mRNAs in SBH/y and SBN/y, with a higher magnitude for SBH/y, than for SBN/y (C, -28 versus -20%; IS, -42 versus -20%). | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 4 | CONCLUSION: A high sodium diet significantly decreases both AT1A and AT1B gene expression in two specific zones of the rat kidney containing the target cells of angiotensin II (C and IS). | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 5 | Finally, SBH/y and SBN/y rats differ in the basal level of AT1 mRNA expression in the IS, and in the ability to modulate AT1 mRNA level under sodium intake. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |