Title : The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase.

Pub. Date : 2000 Jul 14

PMID : 10946853






3 Functional Relationships(s)
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1 Furthermore, TMPZ concentration (50 and 200 microM)- and time (15 and 30 min)-dependently triggered endothelial-type constitutive nitric oxide synthase (ecNOS) protein expression in human platelets. tetramethylpyrazine nitric oxide synthase 3 Homo sapiens
2 Furthermore, TMPZ concentration (50 and 200 microM)- and time (15 and 30 min)-dependently triggered endothelial-type constitutive nitric oxide synthase (ecNOS) protein expression in human platelets. tetramethylpyrazine nitric oxide synthase 3 Homo sapiens
3 These results indicated that TMPZ at micromolar concentrations stimulated nitric oxide production in human platelets via a novel mechanism that activated ecNOS protein expression. tetramethylpyrazine nitric oxide synthase 3 Homo sapiens