Title : Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors.

Pub. Date : 2000 Sep

PMID : 10942851






1 Functional Relationships(s)
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1 This conditioned fear stress response was dose-dependently attenuated by neurosteroids such as dehydroepiandrosterone sulfate (DHEAS; 25 and 50 mg/kg, s.c.) and pregnenolone sulfate (PREGS; 10-50 mg/kg, s.c.), and by a putative sigma(1) receptor agonist, (+)-N-allylnormetazocine ((+)-SKF-10,047; 3 and 6 mg/kg, s.c.). Dehydroepiandrosterone Sulfate sigma non-opioid intracellular receptor 1 Mus musculus