Pub. Date : 2000 Jul 3
PMID : 10936227
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazole (5OH-TBZ), the major metabolite furtherly conjugated, and two minor unidentified metabolites (M1 and M2). | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazole (5OH-TBZ), the major metabolite furtherly conjugated, and two minor unidentified metabolites (M1 and M2). | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 4 | Thus, CYP1A2 is a major isoenzyme involved in the formation of TBZ-derived residues bound to protein. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 5 | Nevertheless, caution is necessary in the use of TBZ concurrently with other drugs able to regulate CYP1A2, particularly in respect to liver and lung tissues, recognised as sites of covalent-binding. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |