Title : Evaluating the role of inducible nitric oxide synthase using a novel and selective inducible nitric oxide synthase inhibitor in septic lung injury produced by cecal ligation and puncture.

Pub. Date : 2000 Aug

PMID : 10934111






2 Functional Relationships(s)
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1 We studied the role of inducible nitric oxide synthase (iNOS) in septic lung injury using a novel and selective iNOS inhibitor (a fused piperidine derivative; ONO-1714) following a cecal ligation and puncture (CLP) procedure. 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane nitric oxide synthase 2 Rattus norvegicus
2 The NO synthase activity in lung homogenates increased from 6 to 24 h after the CLP and thereafter decreased to 42 h. The administration of ONO-1714 inhibited iNOS activity (under calcium-free conditions) in preference to total iNOS activity (under calcium-dependent conditions) in lung homogenates, which thus suggested that this compound selectively inhibited iNOS in lung tissue. 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane nitric oxide synthase 2 Rattus norvegicus