Pub. Date : 2000 Jul
PMID : 10933130
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The low bioavailability of subcutaneously administered factor VIII could have several causes: proteolytic degradation of the protein in the interstitium; adsorption to tissue, in particular to acidic phospholipids such as L-alpha phosphatidyl-L-serine (phosphatidylserine); the absence of free von Willebrand factor in the interstitium; phagocytosis by macrophages in the interstitium or in the lymph nodes; and coagulation could be initiated upon injection. | Phosphatidylserines | cytochrome c oxidase subunit 8A | Homo sapiens |
| 2 | Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates. | Phosphatidylserines | cytochrome c oxidase subunit 8A | Homo sapiens |
| 3 | Including phosphatidylserine in the formulations appeared to increase the availability, of subcutaneously administered r-VIII SQ in the pig. | Phosphatidylserines | cytochrome c oxidase subunit 8A | Homo sapiens |