Protein Name cytochrome c oxidase subunit 8A
Organism Homo sapiens
Gene ID 1351
Gene Symbol


UniProt P10176 (COX8A_HUMAN), Q53XN1 (Q53XN1_HUMAN)
Relationships Total Number of functionally related compound(s) : 1285
Total Number of Articles : 1657

cytochrome c oxidase subunit 8A

Gene Summary

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

  • cytochrome c oxidase subunit 8A, mitochondrial
  • cytochrome c oxidase polypeptide VIII-liver/heart
  • cytochrome c oxidase subunit 8-2
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