Pub. Date : 2000 Oct 20
PMID : 10931829
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of changing the site of activating phosphorylation in CDK2 from threonine to serine. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 2 | Cyclin-dependent kinases (CDKs) that control cell cycle progression are regulated in many ways, including activating phosphorylation of a conserved threonine residue. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 3 | Here we examine the effects of replacing this threonine residue in human CDK2 by serine. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 4 | Combined with the more efficient phosphorylation of CDK2(Ser-160) by CAK, we suggest that one reason for the conservation of threonine as the site of activating phosphorylation may be to favor unphosphorylated CDKs following the degradation of cyclins. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 5 | Combined with the more efficient phosphorylation of CDK2(Ser-160) by CAK, we suggest that one reason for the conservation of threonine as the site of activating phosphorylation may be to favor unphosphorylated CDKs following the degradation of cyclins. | Threonine | cyclin dependent kinase 2 | Homo sapiens |