Title : Histidine-607 and histidine-643 provide important interactions for metal support of catalysis in phosphodiesterase-5.

Pub. Date : 2000 Aug 8

PMID : 10924156






2 Functional Relationships(s)
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1 In cGMP-binding cGMP-specific PDE (PDE5), we showed previously that point mutation of nine of these profoundly decreases k(cat) when the assay is conducted in the presence of Mg(2+); seven of these are in the prototypical metal-binding motifs A and B (HX(3)HX(n)()E) that we identified earlier. Metals phosphodiesterase 5A Homo sapiens
2 In cGMP-binding cGMP-specific PDE (PDE5), we showed previously that point mutation of nine of these profoundly decreases k(cat) when the assay is conducted in the presence of Mg(2+); seven of these are in the prototypical metal-binding motifs A and B (HX(3)HX(n)()E) that we identified earlier. Metals phosphodiesterase 5A Homo sapiens