Title : Terbutaline prevents circulatory failure and mitigates mortality in rodents with endotoxemia.

Pub. Date : 2000 Jul

PMID : 10909895






3 Functional Relationships(s)
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1 In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline. Terbutaline nitric oxide synthase 2 Rattus norvegicus
2 In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline. Terbutaline nitric oxide synthase 2 Rattus norvegicus
3 These findings suggest that the inhibition of TNFalpha and NO (via iNOS) production as well as the increment of IL-10 production contribute to the beneficial effect of terbutaline in animals with endotoxic shock. Terbutaline nitric oxide synthase 2 Rattus norvegicus