Title : Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein.

Pub. Date : 2000 Jul 15

PMID : 10908322






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Excision of FapyGua and 8-OH-Gua by wild-type alpha-hOgg1 was greater than that by alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154). 8-oh-gua 8-oxoguanine DNA glycosylase Homo sapiens
2 The substitution of Arg(154), in addition to diminishing the activity on 8-OH-Gua, relaxes the selectivity found in the wild-type alpha-hOgg1 for the base opposite 8-OH-Gua. 8-oh-gua 8-oxoguanine DNA glycosylase Homo sapiens
3 The substitution of Arg(154), in addition to diminishing the activity on 8-OH-Gua, relaxes the selectivity found in the wild-type alpha-hOgg1 for the base opposite 8-OH-Gua. 8-oh-gua 8-oxoguanine DNA glycosylase Homo sapiens