Pub. Date : 2000 Sep 29
PMID : 10896663
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules. | farnesyl pyrophosphate | farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens |
| 2 | Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules. | farnesyl pyrophosphate | farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens |
| 3 | Because FPP is located at the final branch point in the isoprenoid biosynthesis pathway, its conversion to squalene through the action of squalene synthase represents the first committed step in the formation of cholesterol, making it an attractive target for therapeutic intervention. | farnesyl pyrophosphate | farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens |