PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10896663-2 2000 Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules. farnesyl pyrophosphate 127-147 farnesyl-diphosphate farnesyltransferase 1 Homo sapiens 0-17 10896663-2 2000 Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules. farnesyl pyrophosphate 149-152 farnesyl-diphosphate farnesyltransferase 1 Homo sapiens 0-17 10896663-4 2000 Because FPP is located at the final branch point in the isoprenoid biosynthesis pathway, its conversion to squalene through the action of squalene synthase represents the first committed step in the formation of cholesterol, making it an attractive target for therapeutic intervention. farnesyl pyrophosphate 8-11 farnesyl-diphosphate farnesyltransferase 1 Homo sapiens 138-155