Pub. Date : 2000 Jul
PMID : 10880054
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We tested the hypothesis that DDAVP induces vWF secretion by binding to V2R and activating cAMP-mediated signaling in endothelial cells. | Cyclic AMP | von Willebrand factor | Homo sapiens |
| 2 | vWF secretion from human umbilical vein endothelial cells (HUVECs) can be mediated by cAMP, but DDAVP is ineffective, presumably due to the absence of V2R. | Cyclic AMP | von Willebrand factor | Homo sapiens |
| 3 | We report that DDAVP stimulates vWF secretion in a cAMP-dependent manner in HUVECs after transfection of the V2R. | Cyclic AMP | von Willebrand factor | Homo sapiens |
| 4 | These results indicate that vasopressin induces cAMP-mediated vWF secretion by a direct effect on endothelial cells. | Cyclic AMP | von Willebrand factor | Homo sapiens |