Pub. Date : 2000
PMID : 10874474
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide is known to induce pRb (retinoblastoma gene product) dephosphorylation through the activation of ceramide-activated protein phosphatase (CAPP) during G1 arrest, but other molecular mechanisms linked to regulation of pRb dephosphorylation during ceramide-induced G1 arrest are poorly understood. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 2 | Ceramide is known to induce pRb (retinoblastoma gene product) dephosphorylation through the activation of ceramide-activated protein phosphatase (CAPP) during G1 arrest, but other molecular mechanisms linked to regulation of pRb dephosphorylation during ceramide-induced G1 arrest are poorly understood. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 3 | Ceramide is known to induce pRb (retinoblastoma gene product) dephosphorylation through the activation of ceramide-activated protein phosphatase (CAPP) during G1 arrest, but other molecular mechanisms linked to regulation of pRb dephosphorylation during ceramide-induced G1 arrest are poorly understood. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 4 | In this paper, we investigated whether p21, a cdk (cyclin-dependent kinase) inhibitor, is involved in the induction of pRb dephosphorylation during ceramide-induced G1 arrest. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 5 | In SK-Hep-1 cells, the addition of ceramide resulted in pRb dephosphorylation and G1 arrest. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 6 | Although p21 is induced in ceramide-treated Hep3B cells, Hep3B cells do not induce G1 arrest, because Hep3B cells are deficient in a functional pRb protein. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 7 | After treatment with ceramide, pRb-expressing cells (pRb+/+), but not pRb-/- cells, were arrested in G1 phase. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 8 | After treatment with ceramide, pRb-expressing cells (pRb+/+), but not pRb-/- cells, were arrested in G1 phase. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 9 | After treatment with ceramide, pRb-expressing cells (pRb+/+), but not pRb-/- cells, were arrested in G1 phase. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 10 | In pRb+/+ cells, ceramide-mediated G1 arrest was accompanied by the accumulation of hypophosphorylated pRb and p21 associated with cdk2. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 11 | In pRb+/+ cells, ceramide-mediated G1 arrest was accompanied by the accumulation of hypophosphorylated pRb and p21 associated with cdk2. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |
| 12 | Together, these results suggest that p21, induced through p53-independent pathway, participates in the induction of pRb dephosphorylation by inhibiting cdk2 activity during ceramide-mediated G1 arrest in hepatocarcinoma cells. | Ceramides | RB transcriptional corepressor 1 | Homo sapiens |