Pub. Date : 2000 Jul
PMID : 10871337
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Whereas vincristine and vinblastine at a concentration of 100 nM killed more than 90% of the parental cells, more than 50 and 35%, respectively, of cells that coexpressed CYP3A4 and cytochrome P450 (P450) reductase survived these treatments. | Vinblastine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Similarly, preincubation of vinblastine with bacterial membranes that contained recombinant CYP3A4 and P450 reductase decreased the cytotoxicity of vinblastine for parental Chinese hamster ovary cells. | Vinblastine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Similarly, preincubation of vinblastine with bacterial membranes that contained recombinant CYP3A4 and P450 reductase decreased the cytotoxicity of vinblastine for parental Chinese hamster ovary cells. | Vinblastine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | We also demonstrate that the presence of vinblastine in a coculture of cells that expressed beta-galactosidase together with cells that expressed CYP3A4 strongly selected for the latter cells, resulting in an increased level of CYP3A4 in the surviving cell population. | Vinblastine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Similarly, treatment of the human colon adenocarcinoma cell line LS174T with vinblastine selected for a cell population with higher levels of endogenous CYP3A4 as revealed by immunohistochemistry without simultaneous increase of multidrug resistance protein 1 (MDR1). | Vinblastine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |