Title : 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

Pub. Date : 2000 Jun

PMID : 10866040






3 Functional Relationships(s)
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1 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. acadesine phosphoenolpyruvate carboxykinase 1 Rattus norvegicus
2 We demonstrate here that treatment of hepatoma cells with 5-aminoimidazole-4-carboxamide riboside (AICAR), an agent that activates AMP-activated protein kinase (AMPK), mimics the ability of insulin to repress PEPCK gene transcription. acadesine phosphoenolpyruvate carboxykinase 1 Rattus norvegicus
3 We demonstrate here that treatment of hepatoma cells with 5-aminoimidazole-4-carboxamide riboside (AICAR), an agent that activates AMP-activated protein kinase (AMPK), mimics the ability of insulin to repress PEPCK gene transcription. acadesine phosphoenolpyruvate carboxykinase 1 Rattus norvegicus