Title : NGF stimulation of erk phosphorylation is impaired by a point mutation in the transmembrane domain of trkA receptor.

Pub. Date : 2000 Feb-Apr

PMID : 10854038






1 Functional Relationships(s)
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1 Although the level of basal trkA receptor tyrosine phosphorylation was higher in the mutant than in the wild-type, NGF stimulation of WT 11 and V432E transfectants resulted in a rapid increase in receptor tyrosine phosphorylation and of its intracellular adaptor protein SHC. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus