Title : Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis.

Pub. Date : 2000 Jun 1

PMID : 10850458






2 Functional Relationships(s)
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1 Western blot analysis demonstrated that treatment with As2O3 (2 microM) for 72 h did not change the steady-state levels of CDK2, CDK4, cyclin D1, cyclin E, and cyclin B1 but decreased the levels of CDK6, cdc2, and cyclin A. Arsenic Trioxide cyclin dependent kinase 1 Homo sapiens
2 In addition, As2O3 markedly enhanced the binding of p21 with CDK6, cdc2, cyclin E, and cyclin A compared with untreated control cells. Arsenic Trioxide cyclin dependent kinase 1 Homo sapiens