Title : Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.

Pub. Date : 2000 Jun

PMID : 10835639






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that Th and Dbh deficiencies lead to reduced noradrenaline in the SNS, and that noradrenaline deficiency is a proximal cause of death in mutants by feeding catechol intermediates to pregnant dams, thereby partially averting Gata3 mutation-induced lethality. Norepinephrine tyrosine hydroxylase Mus musculus