Title : Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression.

Pub. Date : 2000 Aug 11

PMID : 10827087






3 Functional Relationships(s)
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1 Here, we report that in NIH3T3 cells, apoptosis in response TNF and cycloheximide is not inhibited by the broad spectrum caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Mus musculus
2 Moreover, treatment with zVAD.fmk sensitizes the cells to the cytotoxic action of TNF. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Mus musculus
3 This hypothesis is further strengthened by the observation that arresting the cells in the G(1) phase of the cell cycle inhibited TNF/zVAD.fmk-induced cell death, whereas blocking them in the G(2)/M phase augmented it. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Mus musculus